Abstract Search

ea0065p35 | Adrenal and Cardiovascular | SFEBES2019

Mitiglinide induces vasodilatory through the activation of voltage-gated K+ channels and SERCA pump in aortic smooth muscle

Jung Hee Seok , Seo Mi Seon , An Jin Ryeol , Na Sung Hun , Park Won Sun

The vasodilatory effects of the meglitinide class of anti-diabetic drug, mitiglinide in phenylephrine (Phe)-pre-contracted aortic rings were investigated. Mitiglinide concentration-dependently induced vasodilation. Administration of the large-conductance Ca2+-dependent K+ (BKCa) channel inhibitor paxilline, inward rectifier K+ (Kir) channel inhibitor Ba2+, and ATP-dependent K+ (KATP) channel inhibitor...

0 shares

ea0065p50 | Adrenal and Cardiovascular | SFEBES2019

Vildagliptin induces vasorelaxation by activation of SERCA pump and Kv channels in aortic smooth muscle

An Jin Ryeol , Seo Mi Seon , Jung Hee Seok , Na Sung Hun , Park Won Sun

In this study, we explored vildagliptin-induced vasorelaxation and its related signaling mechanisms using phenylephrine induced pre-contracted rabbit aortic rings. Vildagliptin induced vasorelaxation in a dose-dependent fashion. Pre-treatment with the large-conductance Ca2+-dependent K+ channel inhibitor paxilline, ATP-dependent K+ channel inhibitor glibenclamide and inward rectifier K+ channel inhibitor Ba2+ did not chang...

0 shares

Endocrine Abstracts

Mitiglinide induces vasodilatory through the activation of voltage-gated K+ channels and SERCA pump in aortic smooth muscle

Vildagliptin induces vasorelaxation by activation of SERCA pump and Kv channels in aortic smooth muscle

BiosciAbstracts